Sodium fusidate

International nonproprietary name

Fusidic acid

Pharmacological group

Natural antibiotic

Active substance

Sodium fusidate (Fusidic acid sodium salt)
 

Chemical formula

C31H47O6Na

Description

White or almost white, crystalline powder.

Molecular mass

538,7

Activity

959 μg/mg

Pharmacological action

Antibacterial, bacteriostatic. It inhibits synthesis of bacteria proteins. It is active against Staphylococcus spp., including the most strains of S. aureus (incl. methicillin-resistant, MRSA) и S. epidermidis (incl. methicillin-resistant), also against Corynebacterium spp., Cladosporium spp. It is also effective against different staphylococci resistant to penicillins, streptomycin, chloramphenicol, erythromycin.
After oral administration it is well adsorbed from gastrointestinal tract, not degraded in stomach.
It is distributed to tissues and fluids of an organism: penetrate into skin, hypodermic tissue, lungs, nephroses and liver, pleural exsudate, cartilaginous and copulative tissues, it is accumulated into osteal tissue in significant amounts. After topical application it deeply penetrates into skin in the affected areas. After application in form of ophthalmic drops it well penetrates into intraocular fluid.

The use of drugs based on 'Sodium fusidate'

Oral:diseases caused by sensitive microorganisms (including staphylococci resistant to other antibiotics) – hematosepsis, pneumonia, otitis, infections of skin and soft tissues (furunculosis, pyoderma, sycosis, contaminated wounds, combustions, etc.), osteomyelitis; gonorrhea caused by gonococci strains resistant to benzylpenicillin, or at hypersensitivity of a patient to penicillins.
I.v.:serious infectious-inflammatory diseases caused by multi-resistant strains of staphylococci and other sensitive microorganisms (especially at patients with allergic reactions on penicillins and other antibiotics) –pneumonia, sepsis, septic endocarditis, meningitis, osteomyelitis, purulent infections of soft tissues.
Topical: infections of skin and soft tissues caused by sensitive microorganisms, including impetigo, furuncles, hydradenitis, contaminated wounds, beard sycosis, paronychia, folliculitis, carbuncles, erythrasma.
Conjunctival: bacterial infections of eyes caused by sensitive microorganisms.

Certification

Certificate of suitability of the monograph of the European Pharmacopoeia issued by the EDQM No. R0-CEP 2008-207-Rev 00.

Packing

Two-layer polyethylene bags 1; 1,5; 2,5 kg into tin canisters.

Drugs produced OJSC «BIOSINTEZ», based on the substance 'Sodium fusidate'

-Sodium fusidate tablets, coated enterosoluble 125 mg, 20 pcs
-Sodium fusidate tablets, coated enterosoluble 250 mg, 20 pcs
-Fusimet ointment for topical use 25 g

Storage conditions

In an airtight container, protected from light, at a temperature of 2 °C to 8 °C.

Expiration date

2 years